在埃及隐藏的乙型肝炎病毒感染的流行:一个系统的综述与元分析
Ahmed Azzam1, Heba Khaled2, Esraa S El-Kayal3
1Department of Microbiology and Immunology, Faculty of Pharmacy, Helwan University, Ain Helwan, Cairo, Egypt. ahmed.abdelkareem@pharm.helwan.edu.eg.
The Journal of the Egyptian Public Health Association
|July 25, 2023
概括
隐性乙型肝炎病毒 (HBV) 感染在埃及很普遍,特别是在献血者和高风险群体中. 核酸放大测试 (NAT) 可以提高输血安全性,但需要评估成本效益.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 隐性乙型肝炎病毒 (HBV) 感染 (OBI) 构成严重的公共卫生风险,因为它在低病毒载荷下具有可传播性,并且在免疫抑制下可能会重新激活.
- 了解埃及OBI的流行程度对于有针对性的干预至关重要,特别是在献血者和高风险人群中.
研究的目的:
- 确定埃及隐性乙型肝炎病毒感染 (OBI) 的综合流行率.
- 分析不同人群中的OBI患病率,包括献血者,血液透析患者和慢性肝病患者.
主要方法:
- 使用PRISMA指南进行了系统的文献审查和元分析,搜索了PubMed,Scopus,Google Scholar和Web of Science等数据库,直到2022年10月.
- 使用I-平方和Cochran的Q统计数据来评估异质性,结果以比例 (%) 和95%置信区间 (CI) 报告,使用随机效应模型.
- 进行了子组和敏感性分析,以探索基于人口类型和研究强度的流行率变化.
主要成果:
- 分析包括50项研究,揭示了各种群体的OBI流行率显著.
- 在HBsAg阴性群体中,多次输血患者的OBI患病率最高 (41%),其次是肝细胞癌患者 (24%),血液透析患者 (17%) 和慢性肝炎C (HCV) 患者 (10%).
- 在HBsAg阴性和抗HBc阳性个体中,HCC患者的OBI患病率为31%,慢性HCV患者为15%,献血者为12%. 基因型D是最常见的HBV基因型.
结论:
- 这项研究证实,在埃及的献血者和高风险人群中,OBI的患病率很高.
- 实施HBV核酸放大测试 (NAT) 可以通过检测捐献中的HBVDNA来提高输血安全.
- 在广泛实施之前,建议进一步调查HBV NAT的成本效益.
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