血化学素与全因和疾病特异性死亡率的关联 - 基于人口的研究结果
Katharina Noppes1, Stefan Groß2,3, Anke Hannemann1,2
1Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
International journal of obesity (2005)
|July 25, 2023
概括
高血化学素水平与一般人群中全因死亡风险增加有关. 这种阿迪波金与癌症死亡率显著相关,但与心血管疾病死亡率无关.
科学领域:
- 生物化学 生化学
- 流行病学 流行病学
- 代谢健康 代谢健康
背景情况:
- 横截面研究表明,高化学素和代谢健康不佳之间存在联系.
- 化学素对疾病风险和死亡率的预后价值尚未得到充分研究,特别是在大量未经选择的人群中.
研究的目的:
- 调查血化学素度与全因死亡率之间的关联.
- 检查血化学素与特定原因死亡率 (包括心血管疾病和癌症) 之间的联系.
主要方法:
- 来自波默兰的健康研究 (SHIP-START-1和SHIP-TREND-0) 的两个独立队列的分析.
- 使用多变量Cox比例危险回归模型进行死亡率分析.
- 在考虑竞争性风险时,评估了因特定原因的死亡率.
主要成果:
- 在较高的血化学素度和增加的全因死亡率之间发现了显著的关联,独立于混因素.
- 每增加30ng/mL的海默林与17%更高的全因死亡风险相关.
- 化学素度与癌症死亡率有显著的联系,但与心血管疾病死亡率无关.
结论:
- 血化学素在一个大规模的基于人口的样本中与所有原因的死亡率有关.
- 化学素似乎在与癌症相关的死亡中发挥着重要作用.
- 化学素与心血管死亡率之间没有直接关联.
相关概念视频
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
119
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
119
Psychoneuroimmunology: Cardiovascular Disease
53
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
53
Cancer Survival Analysis
386
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
386


