中部肥胖及其与视网膜年龄差异的关联:来自英国生物银行研究的见解
Ruiye Chen1,2,3, Junyao Zhang3, Xianwen Shang1,2,3
1Department of Ophthalmology, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, China.
International journal of obesity (2005)
|July 25, 2023
概括
中部肥胖,表现为高腰围,与加速衰老有关. 这项研究发现,腰围较高的个体表现出视网膜年龄差距的增加,这表明衰老过程更快.
科学领域:
- 眼科医生 眼科 眼科
- 老年学是指老年学的学科.
- 代谢健康 代谢健康
背景情况:
- 关于衰老和肥胖之间的关系,存在相互矛盾的证据.
- 视网膜年龄,根据 fundus 图像进行估计,作为生物衰老的新生物标志物.
- 这项研究调查了人体表现型与视网膜年龄差异之间的联系.
研究的目的:
- 检查身体质量指数 (BMI) 和腰围 (WC) 现型与视网膜年龄差异之间的关联.
- 为了确定中心肥胖是否与视网膜年龄测量的加速生物衰老有关.
主要方法:
- 利用了35,550名参与者的数据,他们有可用的BMI,WC和视网膜成像.
- 参与者根据BMI和WC分为七个身体组成组分层.
- 采用线性和逻辑回归模型来分析人体测量组与视网膜年龄差异之间的关联.
主要成果:
- 超重/高WC,轻度肥胖/高WC,重度肥胖/高WC组的人与正常体重/正常WC组相比,视网膜年龄差距增加.
- 在完全调整的模型中,这些关联的统计学意义 (P < 0.005) 被观察到.
- 当分析视网膜衰老作为一个明确的结果时,发现了类似的趋势.
结论:
- 中央肥胖和加速衰老之间存在显著的积极关联,视网膜年龄差距表明了这一点.
- 保持健康的身体形状对于缓解加速衰老过程至关重要.
- 视网膜年龄差可以作为一个有价值的指标来评估肥胖对衰老的影响.
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