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Updated: Jul 21, 2025

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
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VBASS可以将单细胞基因表达数据集成到罕见变异的贝叶斯关联分析中

Guojie Zhong1,2, Yoolim A Choi3, Yufeng Shen4,5,6

  • 1Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.

Communications biology
|July 26, 2023
PubMed
概括

这项研究介绍了VBASS,这是一种新的贝叶斯方法,通过整合单细胞表达和de novo变异数据来增强疾病风险基因发现. 维巴斯 (VBASS) 提高了识别疾病遗传贡献的统计能力.

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