血酶用于去除粉样纤维素 (粉样纤维素) 颗粒,用于治疗COVID-19后的病情
Tilly Fox1, Beverley J Hunt2, Robert As Ariens3
1Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
The Cochrane database of systematic reviews
|July 26, 2023
概括
目前的研究不支持粉样纤维素素颗粒导致COVID-19后状态 (PCC) 的说法. 因此,在获得进一步证据之前,不建议使用血合成治疗PCC.
科学领域:
- 生物化学 生化学
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
背景情况:
- 后COVID-19状态 (PCC) 呈现出各种症状,如疲劳和日常功能受损.
- 一个假设表明"微风暴"会引起PCC症状,这导致了对等离子体化治疗的建议.
- 本综述批判性地评估了对粉样纤维素素颗粒和PCC的血酶疗效的实验室研究.
研究的目的:
- 总结和评估PCC中的粉样纤维素素颗粒的实验室研究.
- 通过随机对照试验,评估等离子体酶在PCC患者中去除这些颗粒的安全性和有效性.
主要方法:
- 搜索了PCC中的粉样纤维素颗粒的实验室研究和对等离子体合成的随机对照试验 (RCT).
- 包括调查PCC血中的粉样纤维素素颗粒的研究和关于血酶有效性/安全性的RCT.
- 评估了实验室研究中的偏差风险,并计划分析RCT数据以获得恢复结果.
主要成果:
- 五项实验室研究在PCC,健康人和糖尿病患者中确定了粉样纤维素颗粒.
- 三项研究依赖于视觉成像,缺乏粒子数量或大小的量化.
- 关于研究进行和报告关于粒子与PCC关联或组之间的差异的极限结论的重大问题. 没有确定相关的RCT.
结论:
- 缺乏足够可靠的证据将粉样纤维素素颗粒与PCC病理生理学联系起来.
- 目前没有理由使用等离子酶去除PCC中的这些颗粒.
- 只有在经过精心设计的随机对照试验中,才应该考虑PCC的血合成.
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