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Updated: Jul 21, 2025

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
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一个HUWE1缺陷通过调节BRCA1-∆11q拼接变体导致PARP抑制剂耐药性

Stephen J Pettitt1, Nan Shao2, Diana Zatreanu2

  • 1The CRUK Gene Function Laboratory, The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK. Stephen.Pettitt@icr.ac.uk.

Oncogene
|July 26, 2023
PubMed
概括

降低HUWE1水平增加BRCA1-∆11q,导致同源重组缺陷癌症中对PARP抑制剂 (PARPi) 的耐药性. 这一发现确定HUWE1是特定的BRCA1突变癌症中PARPi耐药性的潜在生物标志物.

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