胃肠道 prokinetics 的使用和帕金森症的风险:一个基于人口的案例交叉研究
Eunji Kim1,2, Siin Kim3,4, Hae Sun Suh3,4,5
1Department of Pharmacy, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
Pharmacoepidemiology and drug safety
|July 26, 2023
概括
胃肠道 (GI) 的 prokinetics显著增加患帕金森病的风险,特别是在老年患者. 仔细考虑肠道内生动学的使用对于预防药物诱导的帕金森症至关重要.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 帕金森症在美国造成了严重的疾病负担.
- 药物诱导的帕金森症 (DIP) 是急性且可逆的,这凸显了识别致病原体的重要性.
- 在高风险人群中预防DIP至关重要.
研究的目的:
- 为了研究胃肠道 (GI) 中的 prokinetic 使用与帕金森症风险增加之间的关联.
- 为了确定消化道内基因药物是否是发展帕金森症的危险因素.
主要方法:
- 采用了采用国家代表性数据的案例交叉研究设计.
- 包括2007年至2015年期间新诊断患有帕金森症的患者 (ICD-10 G20, G21.1, G25.1).
- 在指数日期之前,在风险期 (0-29天) 和控制期 (60-89天) 评估了胃肠道发动机的暴露.
主要成果:
- 消化道前动力学的使用与帕金森病的发生率更高显著相关 (aOR = 2.31).
- 与年轻患者 (aOR = 1.90) 相比,老年患者 (≥65岁) 的风险更明显 (aOR = 2.69).
- 在风险期内,共有2268名患者暴露于肠道肠道内因子.
结论:
- 胃肠道内源性药物的使用是帕金森症的重要危险因素.
- 医疗保健提供者应仔细考虑使用肠道内生动力学,特别是在老年人群中.
- 进一步的研究可能会探索特定的胃肠道发动性剂及其差异性风险.
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