在使用BPaL和其他世卫组织推的二线抗结核药物的RR-TB患者中取得了良好的结果
M C Rikhotso1, S E Ledwaba1, J-P K Ngandu1
1Department of Biochemistry and Microbiology, Faculty of Sciences, Engineering & Agriculture, University of Venda, Thohoyandou.
概括
在南非,使用贝达奎林,普雷托曼尼德和线索利德 (BPaL) 疗法改善了对利芬辛耐药结核病 (RR-TB) 的治疗结果. 接受高活性抗逆转录病毒疗法 (HAART) 的HIV阳性患者显示出更好的结果.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 里芬辛耐药结核病 (RR-TB) 在南非存在重大治疗挑战,失败率低于世卫组织的目标.
- 同时感染艾滋病毒和高活性抗逆转录病毒疗法 (HAART) 影响RR-TB治疗反应.
- 新兴的治疗方案,如贝达基林,普雷托曼尼德和线索利德 (BPaL),为RR-TB治疗提供了新的希望.
研究的目的:
- 评估南非RR-TB治疗中含有BPaL的治疗方案的有效性.
- 评估在现实世界南非RR-TB患者群体中的治疗结果.
- 调查艾滋病毒状态和HAART对BPaL治疗结果的影响.
主要方法:
- 在Medline,PubMed,Google Scholar和Embase进行了系统的文献搜索.
- 包括2015年至2022年间发表的研究,重点关注南非BPaL结果.
- 分析了来自27,259名参与者的数据.
主要成果:
- 对于很大一部分患者来说,BPaL药物是背景治疗方案的一部分 (21%的贝达基林,9%的线索利德).
- 大约68%的患者是艾滋病毒阳性,59%接受HAART.
- 总体而言,66%使用含有BPaL的治疗方案的患者获得了有利的治疗结果.
结论:
- 含有BPaL的疗法在南非证明了RR-TB的治疗结果.
- 接受基于BPaL的治疗的HAART治疗的HIV阳性患者表现得更好.
- 这些发现支持使用BPaL疗法来管理RR-TB,特别是在同时感染的人群中.
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