孕期孕产妇早产和早产前的风险因素:一个基于人口的队列研究
Anne Kvie Sande1,2, Ingvild Dalen3, Erik Andreas Torkildsen1,2
1Department of Obstetrics and Gynecology, Stavanger University Hospital, Stavanger, Norway.
Acta obstetricia et gynecologica Scandinavica
|July 26, 2023
概括
某些孕产妇的健康状况,包括糖尿病 (1型和2型),慢性病和慢性高血压,与早产前症比早产前症更有联系. 这一发现有助于区分早期和晚期孕前的危险因素.
科学领域:
- 产科和妇科 产科和妇科
- 围产儿医学 围产儿医学
- 流行病学 流行病学
背景情况:
- 怀孕前的危险因素经常被研究,而没有区分早产和早产.
- 对于预孕条件是否会对早产前风险和早产前风险产生不同影响的理解有限.
研究的目的:
- 调查糖尿病 (1型和2型),慢性病,喘,,类风湿性关节炎和慢性高血压是否与早产前和晚产前有差异相关.
- 澄清特定的孕产妇健康状况对早期与晚期预先孕风险的不同影响.
主要方法:
- 在挪威 (1999-2016年) 所有出生情况的全国性,基于人口的队列研究.
- 用于计算相对风险比率 (RRRs) 的多项逻辑回归分析,具有95%的置信区间 (CI).
- 根据母亲的年龄,性别平等,多胎妊娠和其他风险因素进行调整.
主要成果:
- 分析了超过100万例分娩;0.9%患有早产前,2.5%患有晚产前.
- 糖尿病 (1型和2型),慢性病和慢性高血压与早产前相比,与早产前的关联明显更强.
- 喘,和类风湿性关节炎没有显示出早产前和晚产前之间的显著差异关联.
结论:
- 糖尿病 (1型和2型),慢性病和慢性高血压与早产前的风险更强烈相关.
- 这些发现突出了基于母亲的并发症的早产和晚产前的不同病因路径.
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