在转移性子宫癌中用化学放射疗法/免疫疗法组合增强abscopal效应:一个病例报告
Wei Zhang1,2, Min Chen1, Qingming Xiang1
1Department of Radiation & Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
本案例研究表明,结合化疗,放射疗法和免疫疗法 (camrelizumab) 有效地治疗了转移性宫癌 (CC) 与肺结节. 这种多模式的方法导致了原发性和转移性瘤的完全缓解.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 癌症研究 癌症研究
背景情况:
- 患有遥远器官的转移性宫癌 (CC) 的预后不好.
- 对于晚期的CC,特别是肺转移,有效的治疗选择有限.
- 标准治疗方法往往对广泛传播的疾病没有足够的疗效.
研究的目的:
- 为了呈现一个肺转移的晚期子宫癌病例.
- 为了评估结合化疗/放射/免疫治疗方案的疗效.
- 突出免疫疗法的潜力,以提高治疗结果和腹腔效应.
主要方法:
- 最初的治疗包括两轮化疗,导致原发性瘤的部分缓解和稳定的肺结节.
- 随后,该患者接受了与camrelizumab (一种免疫治疗剂) 结合的盆腔并发化疗.
- 治疗持续了16个循环的免疫治疗.
主要成果:
- 实现了初级子宫质量的完全缓解.
- 观察到肺结节 (肺转移) 的完全缓解.
- 瘤标志物水平 (状细胞癌抗原) 恢复正常.
结论:
- 化学疗法,放射疗法和免疫疗法 (camrelizumab) 的组合可以对转移性宫癌具有肺部参与的高度有效.
- 这种多模式的方法显示出显著的疗效,导致瘤完全回归.
- 该案例表明,免疫疗法可以增强治疗反应,并可能诱导晚期CC的abscopal效应.
更多相关视频
15:04Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
Published on: January 19, 2019
09:01Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
相关概念视频
Tumor Immunotherapy
Targeted Cancer Therapies
There are several types of targeted therapies against...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
