高敏感性C-反应蛋白在患有先兆子的女性中的纵向概况
Kamini Dangat1, Nisha Wadhwani1, Karuna Randhir1
1Mother and Child Health, Interactive Research School for Health Affairs, Bharati Vidyapeeth (Deemed to be University), Pune, Maharashtra, India.
概括
高灵敏度C反应蛋白 (hs-CRP) 水平在怀孕早期升高,对于患有妊娠前症 (PE) 的女性来说. 然而,hs-CRP在考虑了其他因素后,没有预测PE风险.
科学领域:
- 产科和妇科 产科和妇科
- 免疫学 免疫学 免疫学
- 生物标志物 生物标志物
背景情况:
- C-反应蛋白 (CRP) 是一种炎症标志物.
- 作为先兆子 (PE) 的早期生物标志物,CRP的实用性仍然不确定.
- 在怀孕期间纵向研究高灵敏度CRP (hs-CRP) 是非常重要的.
研究的目的:
- 调查与没有PE的孕妇的纵向hs-CRP水平.
- 为了比较hs-CRP水平在妊娠期间在PE和非PE组.
- 评估hs-CRP与PE风险之间的关联.
主要方法:
- 长度研究涉及324名孕妇 (108名孕妇,216名非孕妇).
- 母亲的血液样本采集于四个间隔:11-14,18-22,26-28周,以及分娩时.
- 血清hs-CRP水平测量和组之间的比较.
主要成果:
- 在孕期11-14周,18-22周和26-28周的PE组中观察到hs-CRP水平升高 (p < .05).
- hs-CRP与整个怀孕期间母亲的血压相关.
- 未经调整的分析显示,更高的早期怀孕hs-CRP与增加的PE风险之间存在关联,但经过对混因素进行调整后,这并不显著.
结论:
- 虽然hs-CRP水平在怀孕早期更高,对于患有PE的女性来说,它们不是PE风险的可靠预测指标.
- 需要进一步的研究来了解炎症标志物在PE发展中的作用.
更多相关视频
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
119
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
119
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
38
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
38
01:30Acute Coronary Syndrome III: Diagnostic Studies
10
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
10