在SARS-CoV-2爆发后,儿童的流感严重程度增加
Gregory Hoy1, Hannah E Maier1, Guillermina Kuan2,3
1Department of Epidemiology, School of Public Health University of Michigan Ann Arbor Michigan USA.
Influenza and other respiratory viruses
|July 26, 2023
概括
随着COVID-19大流行,人口对流感的免疫力下降,导致老年儿童的A/H3N2发病率增加,2022年年轻儿童的A/H3N2发病率增加和更严重的病例.
科学领域:
- 儿童传染病 儿童传染病
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 在全球范围内,SARS-CoV-2流行病扰乱了流感病毒的流通.
- 在大流行期间减少流感暴露可能会降低人口免疫力,特别是在儿童中.
- 这项研究调查了这些变化对尼加拉瓜儿科流感的影响.
研究的目的:
- 为了比较2022年儿童流感A/H3N2和B/维多利亚的发病率和严重程度,与大流行前的季节相比.
- 评估SARS-CoV-2流行病对儿科流感流行病学的影响.
- 为了确定受流感模式变化影响最大的特定年龄组.
主要方法:
- 在尼加拉瓜的马纳瓜进行的前性儿科队列研究.
- 从2022年开始的流感A/H3N2和B/Victoria发病率和严重程度数据与两次大流行前的季节 (2020年之前) 的数据进行比较.
- 根据年龄组分层的分析.
主要成果:
- 与大流行前时期相比,在2022年年长的儿童中观察到流感A/H3N2的发病率更高.
- 2022年发生的严重流感病例比例较大,主要发生在0-4岁儿童中.
- 此外,还分析了流感B/维多利亚的数据以进行比较.
结论:
- 似乎SARS-CoV-2大流行影响了儿科流感的发病率和严重程度.
- 儿童,特别是年轻的儿童,可能在与流行病相关的免疫缺口后面临严重流感的风险增加.
- 调查结果强调,需要在流行后继续对儿科呼吸道感染进行监测.
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