甲状腺激素敏感性与甲状腺受试者的代谢功能障碍相关的脂肪肝疾病之间的关联:一项横截面研究
Huanxin Liu1, Yuling Xing2, Qian Nie1
1Health Examination Center, Hebei General Hospital, Shijiazhuang, Hebei, 050051, People's Republic of China.
概括
自由氨酸与自由甲状腺素的比率 (FT3/FT4) 和甲状腺反量基FT3指数 (TFQIFT3) 的增加与甲状腺功能障碍相关的脂肪肝疾病 (MAFLD) 在无甲状腺患者中更高的患病率有关. 三甘油糖 (TyG) 指数部分调解了这种关系.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 肝脏疾病 肝脏疾病
背景情况:
- 甲状腺激素 (THs) 在脂质代谢中起着至关重要的作用.
- 之前对THs敏感度指数和与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 的研究已经产生了相互矛盾的结果.
- 了解 euthyroid 个体之间的这种关系对于代谢健康至关重要.
研究的目的:
- 调查甲状腺激素敏感度指数与无甲状腺患者的MAFLD之间的相关性.
- 分析各种THs敏感性指标对MAFLD患病率的影响.
- 为了探索甘油三糖 (TyG) 指数的潜在调解效应.
主要方法:
- 分析了6356名无甲状腺参与者的队列.
- 测量了甲状腺激素敏感度指数,包括FT3/FT4比率,TT3RI,TT4RI,TSHI,TFQIFT3和TFQIFT4.
- 使用后勤回归和引导调解分析来评估关联和间接影响.
主要成果:
- 在无甲状腺患者中,MAFLD的患病率为34.47%.
- 更高的FT3/FT4和TFQIFT3水平与MAFLD患病率的增加有关.
- 高FT3/FT4和TFQIFT3仍然是MAFLD的重要风险因素,在调整混因素后,尤其是在年轻人 (≤40岁) 中.
结论:
- 增加FT3/FT4和TFQIFT3与正常甲状腺功能的人群中MAFLD患病率显著相关.
- 三甘油糖 (TyG) 指数部分介导FT3/FT4,TFQIFT3和MAFLD之间的关系.
- 这些发现强调了THs敏感性对代谢健康和MAFLD发展的重要性.
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