手的硬是否反映出糖尿病中内部器官纤维化?
Sanat Phatak1, Jennifer L Ingram2, Pranay Goel3
1Diabetes Unit, King Edward Memorial (KEM) Hospital Research Centre, Pune, India.
Frontiers in clinical diabetes and healthcare
|July 26, 2023
概括
糖尿病手部疾病可能表明广泛的内部器官纤维化. 临床手部检查可以作为一种低成本的查工具,用于识别有风险的糖尿病患者进行纤维化研究.
科学领域:
- 纤维化研究纤维化.
- 糖尿病学 糖尿病学
- 发现生物标志物的发现.
背景情况:
- 纤维化,以组织硬和功能丧失为特征,是慢性疾病发病率和死亡率的主要原因.
- 糖尿病 (第1型和第2型) 与脏和心脏等器官的纤维化有关,并且还通过糖尿病心脏病影响手中的软组织.
- 这些手部疾病,包括关节运动受限和杜普伊特伦病,在组织学上是益纤维的,可能反映出系统性纤维状况.
研究的目的:
- 调查糖尿病患者的手表现是否表明系统性益纤维化状态.
- 探索手部疾病作为糖尿病患者内脏器官纤维化临床生物标志物的潜力.
- 确定使用手部评估来识别易患多器官纤维化的人的可行性.
主要方法:
- 审查有关器官纤维化关联和糖尿病系统性益纤维化因素的流行病学证据.
- 确定测试假设的先决条件,包括测量手部纤维化的方法 (临床/成像得分).
- 提出纵向研究来追踪纤维化进展和手表现的作用.
主要成果:
- 有证据表明,糖尿病的系统性益菌性状态,具有共同的风险因素,如先进的糖化终产物和炎症.
- 一个器官的纤维化在流行病学上与其他器官的纤维化有关,暗示出一种共同的遗传敏感性.
- 手的可访问性使得它成为检测系统性纤维化易感性的实用位置.
结论:
- 糖尿病手状况可以作为系统性纤维化可访问的临床生物标志物.
- 临床手部检查可以提供一种低成本,可扩展的查方法,用于识别患有多器官纤维化风险的糖尿病患者.
- 对手部评估的系统验证可以帮助选择患者参加针对糖尿病纤维化的临床试验.
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