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Updated: Jul 21, 2025

Establishment of an Extracellular Acidic pH Culture System
Published on: November 19, 2017
瘤微环境的pH调节与免疫状态之间的关联
Masahiro Hosonuma1,2,3,4, Kiyoshi Yoshimura1,2,3,4
1Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa University, Tokyo, Japan.
乳酸盐是一种关键代谢物,会使瘤微环境 (TME) 酸化,阻碍抗瘤免疫细胞,促进癌症生长. 本综述探讨了乳酸盐的使用情况.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症新陈代谢 癌症新陈代谢
背景情况:
- 瘤微环境 (TME) 包括各种细胞和影响癌症进展的因素.
- 癌症免疫疗法推进了对TME的理解,揭示了它的动态性质.
- 之前在TME进行的pH调节研究主要集中在乳酸上.
研究的目的:
- 审查瘤微环境中的乳酸介导的pH调节.
- 阐明乳酸对各种TME细胞组件的影响.
主要方法:
- 对研究乳酸生产及其对TME的影响的文献综述.
- 对华堡效应在乳酸分泌和细胞外酸化中的作用的分析.
- 检查乳酸对免疫细胞功能,血管生成和瘤入侵的影响.
主要成果:
- 华堡效应增加了乳酸生产,导致TME酸化.
- 乳酸酸抑制 CD8+ T 细胞,M1 巨细胞和 NK 细胞等关键免疫细胞,促进免疫逃生.
- 乳酸酸的酸化也促进了血管生成,组织重塑,瘤生长和入侵.
结论:
- 乳酸是调节瘤微环境pH的重要因素.
- 乳酸诱导的酸性会损害抗瘤免疫力,并支持瘤的进展.
- 理解乳酸的作用对于开发有效的癌症疗法至关重要.
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