过敏性鼻炎 印度尼西亚家尘后的行为变化 过敏原提取物作为免疫治疗的管理
Yusuf Alif Pratama1, Honey Dzikri Marhaeny1, Lutfiatur Rohmah2
1Master Program of Pharmaceutical Science, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.
Journal of public health in Africa
|July 26, 2023
概括
印尼室内灰尘免疫疗法有效地减少过敏性鼻炎症状,如打喷和鼻子摩擦在小鼠模型. 这种过敏治疗对管理过敏反应有希望.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏学 过敏学
- 药理学 药理学是指药理学的学科.
背景情况:
- 过敏是一种过敏反应,通常由免疫球蛋白E (IgE) 介导,影响全球超过25%的人口.
- 过敏性鼻炎和食物过敏是高度流行的过敏相关疾病.
- 过敏性鼻炎的临床症状包括打喷,鼻,鼻和堵塞.
研究的目的:
- 调查印尼家用灰尘 (IHDM) 过敏原提取物作为过敏性鼻炎免疫疗法的疗效.
- 评估IHDM免疫治疗对与过敏性鼻炎相关的行为变化的影响.
主要方法:
- 这项研究涉及七组,每组有八只雄性BALB/c小鼠.
- 小鼠通过IHDM提取物经历了敏感化 (腹膜内),脱敏化 (皮下) 和挑战 (鼻内) 的阶段.
- 挑战后15分钟观察过敏行为参数,特别是鼻子和打喷.
主要成果:
- 用IHDM提取物作为免疫疗法显著降低了鼻和打喷的频率.
- 与未经治疗的过敏性鼻炎模型相比,在免疫治疗组中观察到这些行为改善.
结论:
- 印度尼西亚家用灰尘免疫疗法有效地降低了过敏性鼻炎的免疫反应.
- 免疫疗法改变了行为参数,表明过敏症状有所减少.
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