Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

302
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
302
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

153
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
153
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

1.6K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.6K
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

300
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
300
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

199
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
199
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

269
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
269

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Macrophage-derived itaconate is a negative regulator of adipose tissue thermogenesis.

Nature metabolism·2026
Same author

Matrix metalloprotease-9 modulates microglial/macrophage responses in murine brain demyelination.

Acta neuropathologica communications·2026
Same author

DESI-MSI applications for direct (spatial) biomolecular analysis of South African natural medicinal products.

Frontiers in plant science·2026
Same author

Blood vessels as primary site of rejection in murine lung transplantation.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same author

Complex non-<i>falciparum</i> transmission and widespread insecticide resistance in Penka-Michel, a hyperendemic malaria focus of the Cameroon highlands.

Research square·2026
Same author

Infants under 24 months with severe malaria have a serological profile of active infection with Epstein Barr Virus.

The Journal of infectious diseases·2026

相关实验视频

Updated: Jul 21, 2025

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
09:04

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

Published on: June 8, 2017

6.6K

严重疟疾儿童的葡萄糖皮质体功能障碍

Leen Vandermosten1, Fran Prenen1, Balotin Fogang2

  • 1Laboratory of Immunoparasitology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.

Frontiers in immunology
|July 26, 2023
PubMed
概括

患有严重疟疾的儿童的皮质醇水平较高,但对葡萄糖皮质醇 (GCs) 的敏感性降低,导致疾病的严重程度. 这项研究研究了疟疾患者的GC反应,揭示了受损的信号通路.

关键词:
皮质醇是一种皮质醇.葡萄糖皮质类药物是什么疟疾 疟疾 是一种疾病.代谢生物组的代谢生物组流感病毒是什么 流感病毒

更多相关视频

A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting
07:27

A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting

Published on: May 16, 2013

18.8K
A Chemical Screening Procedure for Glucocorticoid Signaling with a Zebrafish Larva Luciferase Reporter System
13:22

A Chemical Screening Procedure for Glucocorticoid Signaling with a Zebrafish Larva Luciferase Reporter System

Published on: September 10, 2013

12.0K

相关实验视频

Last Updated: Jul 21, 2025

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
09:04

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

Published on: June 8, 2017

6.6K
A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting
07:27

A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting

Published on: May 16, 2013

18.8K
A Chemical Screening Procedure for Glucocorticoid Signaling with a Zebrafish Larva Luciferase Reporter System
13:22

A Chemical Screening Procedure for Glucocorticoid Signaling with a Zebrafish Larva Luciferase Reporter System

Published on: September 10, 2013

12.0K

科学领域:

  • 免疫学 免疫学 免疫学
  • 内分泌学 在内分泌学.
  • 传染性疾病 传染性疾病

背景情况:

  • 疟疾对全球健康造成重大负担,严重的疟疾极具致命性.
  • 严重的疟疾涉及复杂的病理过程,如免疫激活和代谢失调.
  • 已知上腺荷尔蒙,特别是葡萄糖皮质类药物 (GCs),在感染Plasmodium时对疾病耐受性至关重要.

研究的目的:

  • 在喀麦隆调查未复杂疟疾 (UM),严重疟疾 (SM) 和无症状对照 (AC) 的儿童的葡萄糖皮质激素 (GC) 反应.
  • 为了确定白细胞对疟疾患者GC信号传递的转录敏感性.
  • 为了识别外围血液单核细胞 (PBMCs) 中GCs诱导的代谢变化.

主要方法:

  • 测量了人体和小鼠白细胞中GCs对GILZ和FKBP5的活体诱导.
  • 在PBMC上进行向的痕迹代谢,以检测GC诱导的代谢变化.
  • 在患者队伍中分析了总皮质醇,皮质醇结合型环球蛋白和ACTH水平.

主要成果:

  • 临床疟疾患者的总皮质醇水平升高,特别是在MS组.
  • 在疟疾患者和感染小鼠中,GC诱导的GILZ和FKBP5的表达显著降低.
  • 在患者中观察到酸通路活性增加,独立于皮质刺激;皮质在对照组中增加了cAMP,但在疟疾患者中没有.

结论:

  • 严重疟疾患者表现出皮质醇水平升高,加上GC敏感性降低.
  • 这种受损的GC信号传递可能会对疟疾的发病和严重程度作出重大贡献.
  • 了解GC失调提供了严重疟疾的潜在治疗点.