慢性阻塞性肺病的TCM模式的差异化通过全面的代谢和脂质学表征
Jiansheng Li1,2,3,4, Xinguang Liu1,2,3, Yanmin Shi1,2,4
1Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P.R. China, Henan University of Chinese Medicine, Zhengzhou, China.
Frontiers in immunology
|July 26, 2023
概括
代谢学和脂质学为慢性阻塞性肺病 (COPD) 的三种传统中医 (TCM) 模式确定了不同的代谢标志物. 这项研究澄清了TCM治疗COPD的生物学基础,有助于诊断.
科学领域:
- 生物化学 生化学
- 系统生物学 系统生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性阻塞性肺病 (COPD) 涉及炎症,衰老和自身免疫.
- 传统中医 (TCM) 提供了副作用较少,免疫功能改善的治疗方法.
- 在COPD中区分TCM模式的生物基础需要阐明.
研究的目的:
- 调查COPD的不同TCM模式中的代谢和脂质组差异.
- 为了确定基于TCM的COPD诊断和治疗的潜在生物标志物.
主要方法:
- 分析了来自COPD患者的血清样本 (n=171) 跨越三个TCM模式和健康对照 (n=41).
- 液态染色学-四极管-轨道仪质谱学 (LC-Q-轨道仪MS/MS) 用于代谢学和脂质学.
- 进行了交叉比较,以确定不同的代谢标志物.
主要成果:
- 分别确定了28个,8个和16个差异代谢物,分别用于肺 Qi 缺乏症,肺 - 脏 Qi 缺乏症和肺 - 脏 Qi 缺乏症模式.
- 关键标志物包括皮质醇,低素,脂肪酸和脂.
- 生物标记面板实现了高的诊断准确性 (AUC 0.8810.992,灵敏度 88.697.1%,特异性 81.896.4%).
结论:
- 代谢学和脂质学为COPD TCM模式中的代谢变化提供了全面的观点.
- 代谢差异是TCM独特模式的基础,支持TCM辩证治疗的生物学基础.
- 鉴定的生物标志物可以提高COPD诊断的准确性和基于TCM的治疗策略.
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