电极方向,心肌壁厚度和心肌纤维方向对心内电图的影响:数值建模和分析解决方案
Lore Leenknegt1,2, Alexander V Panfilov3, Hans Dierckx1,2
1Department of Mathematics, KU Leuven Campus KULAK, KU Leuven, Kortrijk, Belgium.
Frontiers in physiology
|July 26, 2023
概括
我们分析计算了心肌内心电图 (iEGM),匹配模拟结果. 这种方法提高了对iEGM及其与心肌特性的关系的理解.
科学领域:
- 生物物理学的生物物理.
- 计算生物学 计算生物学
- 心脏电生理学 心脏电生理学
背景情况:
- 心内电图 (iEGM) 提供了对心脏电活动的关键见解.
- 现有的分析模型往往简化了心肌结构和电特性.
研究的目的:
- 开发和验证心肌板中单极和双极iEGM的分析模型.
- 研究心肌厚度和异质性对iEGM的影响.
- 为iEGMs提供一个定量解释的框架.
主要方法:
- 使用镜子方法对iEGM进行分析计算.
- 对数值双域模拟进行验证.
- 对远距离iEGM衰变和内心表面的行为进行分析.
主要成果:
- 分析解决方案,一个无限序列的角,与双域模拟很好地一致.
- 在很远的距离上,iEGM表现出明显的衰变模式 (1/R,1/R^2,1/R^3).
- 心肌厚度和异质性显著影响iEGM的幅度和宽度.
结论:
- 开发的分析模型提供了一个比固角理论更全面的方法.
- 结果有助于对iEGM的定量解释和选择用于组织特征的值.
- 该模型有助于在未来从iEGMs中推断心脏组织参数.
相关概念视频
01:28Electrocardiogram Fundamentals
644
Introduction
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin...
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin...
644
01:29Electrocardiogram
2.5K
An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
2.5K
01:19Electrophysiology of Normal Cardiac Rhythm
6.3K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
6.3K
01:30Cardiac Action Potential
1.7K
Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
1.7K
01:25Correlation between ECG and Cardiac Cycle
7.1K
The electrical signals recorded on an electrocardiogram (ECG) occur before the mechanical processes of contraction and relaxation during the cardiac cycle.
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
7.1K
01:24Bode Plots Construction
740
The Bode plot is an essential tool in control system analysis, mapping the frequency response of a system through a magnitude plot and a phase plot, both against a logarithmic frequency axis. To construct a Bode plot, consider the transfer function H(ω):
740