人的左侧和右侧部迷走神经中的交感元件:对迷走神经刺激的影响
Tom J H Ruigrok1, Sophia A Mantel1,2, Lara Orlandini1,2
1Department of Neuroscience, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
Frontiers in neuroanatomy
|July 26, 2023
概括
这项研究证实了宫迷走神经中潜在的交感性诺亚上腺素纤维. 了解它们的可变分布对于优化宫迷走神经刺激协议至关重要.
科学领域:
- 神经科学是一个神经科学.
- 人体解剖学 解剖学 解剖学
- 临床神经学 临床神经学
背景情况:
- 宫迷走神经刺激是一种广泛使用的临床治疗方法.
- 众所周知,部迷走神经含有各种纤维类.
- 最近的发现表明,在这个神经内存在潜在的诺亚上腺素效应的交感纤维.
研究的目的:
- 确认在人类部迷走神经组织中存在氨酸氧酶 (TH) 阳性纤维.
- 研究这些纤维的起源,方向,分布和变异性.
- 为了帮助开发最佳的宫迷走神经刺激协议.
主要方法:
- 人类迷走神经样本从尸体中获得.
- 使用抗TH抗体,髓基蛋白和神经纤维的免疫组织化学技术.
- 分析的重点是纤维的存在,起源,过程,分布和可变性.
主要成果:
- 至少有一些TH阳性纤维来自上性宫腺或交感干.
- 这些TH-阳性纤维沿着神经内的外围路径.
- TH阳性纤维的比例在个体之间以及在左神经和右神经之间有很大差异,在左神经中通常会逐渐减少.
结论:
- 这项研究证实了部迷走神经中交感纤维的存在和变化性质.
- 这些发现强调了考虑交感纤维分布的重要性,以有效地刺激迷走神经.
- 这种解剖学的理解可以引导对临床刺激参数的改进.
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