单个血清皮质醇值作为急性缺血性中风的预后标志物
Gurjeet Saini1, Kamaldeep Kaur2, Lovleen Bhatia1
1Department of Medicine, Government Medical College, Patiala, Patiala, IND.
Cureus
|July 26, 2023
概括
血清皮质醇水平表明急性缺血性中风 (AIS) 的严重程度和预后. 在AIS患者中,较高的基线皮质醇与更糟糕的结果和增加的死亡率相关.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 临床医学 临床医学
背景情况:
- 在全球范围内,中风是导致死亡和残疾的主要原因.
- 急性缺血性中风 (AIS) 引发了涉及下丘脑-垂体-上腺 (HPA) 轴的应激反应.
- 在AIS患者中观察到内分泌变化,包括血清皮质醇升高.
研究的目的:
- 为了研究血清皮质醇作为急性缺血性中风的预后标志物.
- 评估基线血清皮质醇水平和中风严重程度之间的关系.
- 评估血清皮质醇与短期和长期功能结果和死亡率的相关性.
主要方法:
- 对100名AIS患者进行前性观察研究.
- 测量了基线血清皮质醇水平.
- 使用NIHSS评估中风严重程度;使用mRS在1,4和24周的功能结果.
主要成果:
- 在血清皮质醇和中风严重程度 (NIHSS) 之间发现了正相关性.
- 血清皮质醇与1周,4周和24周的功能不良结果 (mRS) 有显著的相关性.
- 较高的血清皮质醇水平与AIS患者的死亡率增加有关.
结论:
- 血清皮质醇增加反映了AIS中有害的压力反应.
- 基线血清皮质醇是AIS严重程度,结果和死亡率的有价值的预后标志物.
- 这一发现支持使用血清皮质醇用于AIS中的风险分层.
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