兄弟姐妹和过敏性鼻炎的风险:系统性审查和元分析
Daniil Lisik1, Saliha Selin Özuygur Ermis1,2, Athina Ioannidou1
1Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
概括
晚出生的孩子和那些有更多兄弟姐妹的孩子有较低的过敏性鼻炎的风险. 这一元分析证实出生顺序和兄弟姐妹的规模是防止过敏性鼻炎发展的保护因素.
科学领域:
- 流行病学 流行病学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- "卫生假设"表明,在生命早期减少对微生物的暴露会增加亚托皮性疾病的风险.
- 关于Sibship成分在过敏性鼻炎中的保护作用的研究显示了相互矛盾的结果.
- 过敏性鼻炎的流行率在全球范围内有所增加,需要对导致因素进行调查.
结论:
- 出生次序较高是对过敏性鼻炎的主要保护因素.
- 更大的兄弟姐妹尺寸也有助于降低患过敏性鼻炎的风险.
- 这些发现支持了家庭结构中早期环境暴露在调节过敏风险中的作用.
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