脂质组植物作为LDL胆固醇降低剂在饮食引起的高脂血症中
Asmita Poudel1, George Gachumi1, Phyllis G Paterson1
1College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon S7N 5E5, Saskatchewan, Canada.
Molecular pharmaceutics
|July 26, 2023
概括
这项研究表明,一种新的脂肪体配方的植物固醇 (PSs),包括brassicasterol,有效地降低了子的LDL-C. 脂质体PSs与商业产品一样有效,无论使用的载体是什么.
科学领域:
- 营养生物化学 营养生物化学
- 预防心血管疾病 预防心血管疾病
- 脂质代谢 脂质代谢是什么
背景情况:
- 高低密度脂蛋白胆固醇 (LDL-C) 是一种主要的心血管疾病风险因素.
- 植物固醇 (PSs) 降低了LDL-C,配方影响了疗效.
- 布拉西卡斯托尔是一种天然丰富的PS,尚未对其降低LDL-C的效果进行评估.
研究的目的:
- 评估一种新型脂肪体配方的有效性,该配方含有天然的PS混合物,包括布拉西卡斯托尔,可降低LDL-C.
- 为了比较新型脂质体PS配方与市场上销售的PS产品和对照组在子模型中的疗效.
主要方法:
- 使用了一个高胆固醇血症的仓鼠模型,养高脂肪,补充胆固醇的饮食.
- 动物被用脂质体PS (在汁或水中),销售PS (在汁中) 或对照车辆治疗了4周.
- 禁食血液样本被分析为总胆固醇,LDL-C,HDL-C,和三糖在基线,第2周和第4周.
主要成果:
- 与对照组相比,汁和水中的脂质体PS配方显著降低了LDL-C.
- 这种新型脂质体PS配方的降低LDL-C的效果与市场上销售的PS产品相比相当.
- 脂质体PSs降低LDL-C的疗效在不同载体 (汁和水) 中是一致的.
结论:
- 一种新的天然植物类固醇的脂质体配方,包括布拉西卡斯托尔,在仓鼠模型中有效降低了LDL-C.
- 脂质体封装增强了PS的疗效,这种配方与商业PS产品一样有效.
- 脂质体PS配方对心血管健康有前途,无论食物矩阵如何,有效性都是一致的.
更多相关视频
相关概念视频
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
699
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
699
Lipids: Dietary Sources and Requirements
843
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
843
Blood Studies for Cardiovascular System III: Serum Lipid Profile
197
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
197
Cholesterol: Significance and Regulation
588
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
588
Overview of Fatty Acid Metabolism
30.8K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
30.8K
Lipid Absorption
530
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
530


