益生菌用于预防非常早产或出生体重非常低的婴儿死亡性肠球炎
Sahar Sharif1, Nicholas Meader1, Sam J Oddie1,2
1Centre for Reviews and Dissemination, University of York, York, UK.
The Cochrane database of systematic reviews
|July 26, 2023
概括
益生菌补充剂可能会降低死角 enterokolitis (NEC) 的风险和非常早产婴儿的死亡率. 然而,证据质量低至中等,需要对极度早产婴儿进行进一步的研究.
科学领域:
- 新生儿医学 新生儿医学
- 微生物组研究 微生物组研究
- 胃肠病学 胃肠病学
背景情况:
- 肠道失生症与非常早产和出生体重非常低 (VLBW) 婴儿的死角性肠球炎 (NEC) 病原发生有关.
- 正在探索益生菌补充剂以调节肠道微生物群并降低NEC风险.
研究的目的:
- 评估益生菌补充剂对非常早产或VLBW婴儿的NEC风险,死亡率和发病率的影响.
- 评估对晚期发病的侵入性感染和神经发育结果的影响.
主要方法:
- 60个随机对照试验 (RCT) 和准RCT的系统审查和元分析.
- 包括非常早产 (<32周怀孕) 和VLBW (<1500g) 的婴儿.
- 综合了使用风险比率和置信区间对NEC,死亡率,感染和神经发育的数据.
主要成果:
- 益生菌可以降低非常早产/VLBW婴儿的NEC风险 (RR 0.54) 和死亡率 (RR 0.77),证据确定性低至中等.
- 观察到对晚期发病的侵入性感染或神经发育障碍几乎没有影响.
- 对极度早产/ELBW婴儿的有限数据显示,对NEC,死亡率或感染没有显著影响.
结论:
- 益生菌对非常早产/VLBW婴儿的NEC和死亡率显示出潜在的益处,但证据质量有限.
- 进一步进行高质量的试验至关重要,以确认疗效并指导临床实践,特别是对于极度早产婴儿.
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