胚胎内膜腺增殖的演变频谱具有带状和化特征
Jennifer Pors1,2, Julianna J Weiel1,3, Emily Ryan1
1Department of Pathology, Stanford University School of Medicine, Stanford, CA.
The American journal of surgical pathology
|July 26, 2023
概括
带绳和化 (CH) 子宫内膜增生是一种明显的前体病变. 保守治疗显示出有利的结果,但进展到癌症是可能的,强调需要仔细监测.
科学领域:
- 妇科病理学 妇科病理学
- 瘤历史学 瘤历史学
背景情况:
- 认出了带有带状和化 (CH) 特征的子宫内膜腺增殖.
- 这些特征通常与子宫内膜癌有关.
研究的目的:
- 呈现CH特征的子宫内膜病变的临床病理学和免疫组织化学特征.
- 评估这些病变的临床行为和治疗结果.
主要方法:
- 对14个带有CH特征的子宫内膜腺增殖的回顾性分析.
- 组织学检查,包括对建筑复杂性和细胞学异常的评估.
- 针对β-catenin,雌激素受体,PTEN,MSH6,PMS2和p53.5的免疫组织化学分析.
主要成果:
- 病变的范围从增生症到分化良好的子宫内膜腺癌和坦率的带绳和化子宫内膜癌 (CHEC).
- 它们的共同特征包括状细胞,状分化和骨性转化.
- 在所有病例中都存在异常的核β-catenin;其他标记物基本上是不显著的.
- 具有CH特征的增生症在孕激素治疗中表现出良好的结果,而与CHEC相邻的病变进展为腺癌.
结论:
- 甲状腺癌的形态发生在整个子宫内膜瘤扩散的频谱中,不仅仅发生在癌症中.
- "带绳和化子宫内膜异位增生症"被提议作为前体病变的术语.
- 保守的治疗可能对CH特征的增生症有效,但对恶性潜在的警是有必要的.
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