乳杆菌paracasei ET-22和衍生后生物降低口臭和调节口腔微生物组失调 - 一个随机,双盲,安慰剂控制的临床试验
Guna Wuri1, Fudong Liu2,3, Zhe Sun1
1School of Food and Health, Beijing Technology and Business University, Beijing 100024, China. zhangming@th.btbu.edu.cn.
Food & function
|July 26, 2023
概括
在活体和热杀死形式的Lactobacillus paracasei ET-22,通过减少挥发性硫化合物和改变口腔微生物组合,有效地减少了口臭. 这种益生菌干预措施对控制口气不良有前途.
科学领域:
- 口腔微生物学 口腔微生物学
- 益生菌 益生菌 益生菌
- 化病研究研究 化病研究
背景情况:
- 口腔微生物失生症是口臭的主要原因.
- 针对口腔微生物组提供了口臭的预防策略.
- 乳杆菌虫ET-22正在研究其对口臭的潜在影响.
研究的目的:
- 评估Lactobacillus paracasei ET-22 (活体和热杀死) 对口臭的疗效.
- 分析ET-22对口腔微生物组合和挥发性有机化合物 (VOC) 的影响.
主要方法:
- 随机对照试验与68口臭病患者在安慰剂,ET-22活,和ET-22热杀死组.
- 干预涉及4周每天服用三次药片.
- 唾液样本分析了挥发性硫化合物 (VSC),唾液VOC (HS-SPME-GC/MS) 和微生物组概况 (16S rRNA基因测序).
主要成果:
- 在ET-22活体和热杀死组中观察到呼吸中VSC的显著减少,在活体组中更为明显.
- 干预改变了唾液的VOC概况,显著减少了像醇和胺这样的不良化合物.
- ET-22调节了口腔微生物组,减少了与口臭相关的病原体,例如Rothia,Streptococcus,Solobacterium和Peptostreptococcus.
结论:
- 活体和热杀死的Lactobacillus paracasei ET-22都有效地抑制了口臭患者的不良气味化合物产生.
- 这些有益影响与口腔微生物组的分类构成的显著变化有关.
- 乳杆菌虫ET-22为口臭管理提供了一个可行的益生菌策略.
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