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Updated: Jul 21, 2025

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在单细胞水平上,沃尔登斯特罗姆巨型球蛋白血症的克隆结构和进化史

Ramón García-Sanz1, María García-Álvarez1, Alejandro Medina1

  • 1Hematology Department, University Hospital of Salamanca (HUS/IBSAL), CIBERONC and Cancer Research Institute of Salamanca-IBMCC (USAL-CSIC), Salamanca 37007, Spain.

Disease models & mechanisms
|July 26, 2023
PubMed
概括

单细胞分析揭示了沃尔登斯特罗姆的大球蛋白血症 (WM) 的克隆演变. MYD88L265P在早期阶段是关键的,而症状性疾病显示出协同作用的变化,推动了扩张和治疗影响了克隆多样性.

关键词:
疾病机制 疾病机制基因组的改变 基因组的改变蛋白质表达方式 蛋白质表达方式单细胞机是一种单细胞机.沃尔登斯特罗姆的巨型球蛋白血症

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