通过全基因组积极选择,揭示了原生牛品种的外套颜色变异背后的基因
Divya Rajawat1, Manjit Panigrahi1, Sonali Sonejita Nayak1
1Division of Animal Genetics, Indian Veterinary Research Institute, Izatnagar, Bareilly, India.
Animal biotechnology
|July 26, 2023
概括
我们在印度牛的选择性扫描下确定了16个基因,揭示了对外套颜色变异和进化的遗传见解. 这些发现揭示了塑造牛颜色的进化力量.
科学领域:
- 遗传学 是一个遗传学.
- 进化生物学 进化生物学
- 动物科学动物科学
背景情况:
- 牛的外套颜色变化受到色素基因的影响.
- 了解土著牛品种的选择性扫除事件对于进化见解至关重要.
- 以前的研究已经确定了外套颜色的候选基因,但缺乏全基因组选择分析.
研究的目的:
- 在印度土著牛品种的选择性扫除下识别外套颜色基因.
- 为了研究色素的遗传基础和塑造外套颜色变化的进化力量.
- 为在牛外套颜色基因中提供全面的全基因组扫描以寻找积极选择特征.
主要方法:
- 编制了候选外套颜色和色素基因的列表.
- 通过使用BovineSNP50K珠芯片在7个土著品种的187个个体中进行了全基因组扫描以获得积极选择.
- 应用了多种统计方法,包括塔吉马的D,CLR,iHS,varLD,ROH和FST来检测选择签名.
主要成果:
- 在选择性扫描下确定了16个与外套颜色和色素生理学相关的基因.
- 在各种印度牛品种中检测到MC1R,ASIP,TYR,TYRP1和KIT等特定基因.
- 这些被选中的基因参与了黑色素合成,黑色素细胞生物学和黑色素生成.
结论:
- 选择性扫描对印度牛的外套颜色和色素基因产生了重大影响.
- 这些已识别的基因为理解牛毛颜色进化提供了关键的遗传标记.
- 这项研究提供了有价值的见解,了解了土著牛的遗传结构和色素的适应性进化.
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