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从差异化甲状腺癌的骨转移:多中心系列中的特征和预后因素
Ana Piñar-Gutiérrez1, Ana R Romero-Lluch1, Suset Dueñas-Disotuar1
1UGC Endocrinología y Nutrición, Hospital Universitario Virgen del Rocío, Sevilla, España.
European thyroid journal
|July 26, 2023
概括
带有骨转移的分化甲状腺癌的存活率受到治疗和疾病传播的影响. 不接受I131治疗的患者,结节参与或其他转移的患者的存活率较低.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 医学研究 医学研究
背景情况:
- 分化甲状腺癌 (DTC) 可以转移到骨 (BMs).
- 了解DTC患者的生存和预后因素对于临床管理至关重要.
- 关于DTC患者在现实环境中患有BM的特征和结果的数据有限.
研究的目的:
- 描述来自DTC的BM患者的特征.
- 分析生存率并确定DTC的BM患者的预后因素.
- 评估I131和多酶抑制剂等治疗对生存的影响.
主要方法:
- 多中心回顾性观察性研究.
- 包括1980年至2021年期间从DTC诊断出患有BM的患者.
- 预后因素的考克斯回归和Kaplan-Meier/log-rank测试用于生存分析.
主要成果:
- 63名患者被评估,随访时间中位数为35个月.
- 最常见的组织学是乳头变异 (60.3%),脊椎是最常见的BM位置 (60.3%).
- 5年和10年的整体生存率分别为42.4%和20.4%. 显著的预后因素包括淋巴结的参与和I131.1的治疗.
结论:
- 在DTC与BMs的现实管理中,结节参与或其他转移的患者的存活率较低.
- 用I131治疗与5年和10年生存率的改善有关.
- 这些发现凸显了在DTC患者结果中考虑转移性传播和治疗选择的重要性.
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