植物性,凝类微纤维作为一种抗氧化平台,用于治疗皮肤烧伤和愈合
Fabrizio Fiorentini1,2, Giulia Suarato1,3, Maria Summa3
1Smart Materials Group, Istituto Italiano di Tecnologia, Via Morego 30, Genova 16163, Italy.
ACS applied bio materials
|July 26, 2023
概括
这项研究开发了含有维生素C (VitC) 的植物性微纤维支架,用于伤口愈合. 这些环保的支架促进皮肤愈合,减少炎症,为生物医学应用提供可持续的替代方案.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 再生医学是一种再生医学.
背景情况:
- 来自有机废物的天然聚合物被探索为生物医学设备.
- 皮肤贴片和带需要短期支持和生物降解材料.
- 维生素C (VitC) 是一种具有伤口愈合和紫外线保护特性的生物活性分子.
研究的目的:
- 设计和描述含有维生素C (VitC) 的植物微纤维支架.
- 评估这些支架在促进皮肤伤口愈合和减少炎症方面的有效性.
- 评估这些支架作为皮肤贴片的环保替代品的潜力.
主要方法:
- 通过电制造的简/pectin微纤维的制造,装有维生素C.
- 与Ca2+交叉连接支架以实现类似水凝的行为和控制降解.
- 使用人类皮肤纤维细胞和HaCaT细胞进行物理化学表征和生物活性评估.
- 在体内对UVB烧伤小鼠模型进行体内测试,以评估抗炎作用.
主要成果:
- 齐恩/pectin/VitC支架展示了可调节的药物释放和降解概况.
- 释放的VitC刺激了皮肤纤维细胞中原蛋白mRNA的产生.
- 支架表现出抗氧化活性,保护HaCaT细胞免受氧化应激.
- 在体内测试显示,UVB损伤皮肤的炎症性细胞因子显著减少 (50%).
结论:
- 含有VitC的植物性微纤维支架对皮肤伤口愈合有效.
- 这些支架提供抗氧化和抗炎性质,促进组织修复.
- 开发的材料代表了传统皮肤贴片的有希望的,可持续的替代品.
更多相关视频
08:40Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection
Published on: August 23, 2022
4.9K
10:05Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
Published on: May 8, 2020
2.0K
相关概念视频
01:19Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
01:22Burn Injuries
2.6K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
2.6K