胃肠囊淋巴瘤的发病:基于组织病理学和内镜发现的考虑
Yuka Takahashi1, Hirokazu Taniguchi1,2, Furukawa Haruhi3
1Departments of Diagnostic Pathology.
The American journal of surgical pathology
|July 26, 2023
概括
胃肠卵泡淋巴瘤 (GI FL) 主要发生在小肠,根据位置有明显的内镜特征. 组织病理学在各位点都是一致的,尽管小肠粘膜可能更好地揭示早期的GI FL.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 胃肠卵泡淋巴瘤 (GI FL) 是最常见的外节性淋巴瘤形式,但其起源和表现不同.
- 了解GI FL的分布和特征对于诊断和管理至关重要.
研究的目的:
- 为了调查GIFL的分布,内镜外观和其病理学特征.
- 探索胃肠道部位,粘膜结构和FL呈现之间的潜在相关性.
- 评估转变为更具攻击性的淋巴瘤亚型的风险.
主要方法:
- 追溯分析来自298名患者的366个GI FL样本.
- 对内镜和组织病理学发现的审查,包括免疫组织化学 (CD10,BCL2).
- 主要和次要GIFL之间以及不同GI位置的发现结果的比较.
主要成果:
- 最常见的FL是在小肠 (71%),其次是胃 (15%) 和结肠 (12%).
- 颗粒状病变常见于十二指肠 (74%) 和末端大肠 (39%),罕见于胃 (0%).
- 大多数病例显示1-2级组织学 (89%) 与CD10+ (93%) 和BCL2+ (98%) 标志物;转化发生在7%的初级GIFL.
结论:
- 胃肠道炎症发病率和内镜检测结果因部位而异,可能是由于粘膜结构的差异.
- 组织病理在很大程度上是一致的,但小肠粘膜的特征可能有助于检测早期FL.
- 胃肠道FL携带转变为扩散大B细胞淋巴瘤或高度B细胞淋巴瘤的风险.
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