评估儿童自身免疫脑炎的患者与典型和非典型的先发性神经精神病发育的患者的回顾性比较
Kira Panzer1, Alexis Harmon2, Reginald Lerebours3
1Duke University School of Medicine, Durham, NC, USA.
Journal of autism and developmental disorders
|July 26, 2023
概括
自身免疫性脑炎 (AE) 在有或没有神经发育障碍 (NDD) 的儿童中表现相似. AE影响了NDD患者的多个临床领域,使他们与没有AE的同龄人区别开来.
科学领域:
- 神经科学是一个神经科学.
- 儿科 儿科 儿科
- 免疫学 免疫学 免疫学
背景情况:
- 神经发育障碍 (NDD) 包括自闭症和发育迟缓等疾病.
- 患有NDD的患者越来越多地呈现出暗示自身免疫性脑炎 (AE) 的症状.
- 将AE与基线NDD症状区分开来可能是临床上具有挑战性的,因为症状重叠.
研究的目的:
- 根据神经发育状态,探索自身免疫脑炎 (AE) 特征的差异.
- 为了比较典型发育儿童与NDD儿童的AE临床表现.
主要方法:
- 对67名被评估为AE的儿童进行了回顾性图表审查.
- 在三个组之间对AE临床领域,症状发作和治疗反应进行比较:AE的典型发展 (TD-AE),AE的NDD (NDD-AE) 和没有AE的NDD (NDD-nonAE).
- AE诊断包括具有抗NMDAR或抗GAD抗体的血清阴性AE或血清阳性AE.
主要成果:
- 患有AE的儿童表现出比没有AE的NDD儿童报告的临床领域更多,无论发育状态如何.
- 在TD-AE和NDD-AE组之间没有发现报告的临床领域的显著差异.
- 在这三个组中,症状发作的严重程度各不相同,治疗反应相似.
结论:
- 自身免疫性脑炎 (AE) 在患有神经发育障碍 (NDD) 和没有神经发育障碍 (NDD) 的儿童中具有相当数量的临床领域.
- 与没有AE的NDD患者相比,被诊断为AE的NDD患者显示出更多的临床领域.
- 在典型发育的儿童和患有NDD的儿童中,AE的特征是多域状况.
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