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在急性淋巴细胞白血病的维持治疗:临床初步治疗

Shekhar Krishnan^1,2,3, Ananya Mahadevan⁴, Tushar Mungle⁴

¹Clinical Research Unit, Tata Translational Cancer Research Centre, Tata Medical Center, 14 Major Arterial Road (East-West), Newtown, Rajarhat, Kolkata, West Bengal, 700160, India. shekhar.krishnan@ttcrc.tmckolkata.org.

Indian journal of pediatrics

|July 26, 2023

概括

儿科急性淋巴细胞白血病维持治疗 (ALL-MT) 需要仔细剂量6 - 默卡波图 (6MP) 和甲状腺素 (MTX). 个性化治疗调整对于最佳结果和最小化儿童毒性至关重要.

科学领域:

儿科瘤学儿科瘤学
药理学药理学是指药理学的学科.
血液学血液学血液学

背景情况:

儿童急性淋巴细胞白血病 (ALL) 治愈率在发达国家接近90%.
所有的治疗包括密集化疗,然后24个月的维持疗法 (ALL-MT).
所有的MT依赖于每天口服的6 - 默卡普托普林 (6MP) 和每周口服的甲状腺素 (MTX).

研究的目的:

审查管理ALL维持治疗 (ALL-MT) 的挑战和策略.
根据患者的耐受性,强调6MP和MTX的个性化剂量.
专注于ALL-MT管理的印度背景.

主要方法:

审查当前的ALL-MT协议和管理策略.
讨论影响药物耐受性的因素 (遗传和非遗传).
强调临床评估和血清监测的重要性.

主要成果:

低于最佳的ALL-MT强度与较差的患者结果相关.
由于不坚持或有毒性的治疗中断可能会对结果产生负面影响.
个性化剂量和密切监督对于有效的ALL-MT至关重要.

结论:

有效的ALL-MT需要在最高耐受剂量的药物中不间断治疗.
管理需要仔细监测,剂量调整,并尽量减少治疗中断.
优化ALL-MT的策略至关重要,特别是在印度医疗保健环境中.

关键词:

6 - 甲普氨酸是什么?急性淋巴细胞白血病 (Acute Lymphoblastic Leukemia) 是一种急性淋巴细胞白血病.维护疗法维护疗法甲基甲酸二醇的使用方法

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