在验尸官死后毒理学分析中检测到的中毒和非中毒相关自杀的物质
Jessy S Lim1,2, Nicholas A Buckley1,3, Rose Cairns2,3
1Biomedical Informatics and Digital Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
JAMA psychiatry
|July 26, 2023
概括
药物使用与自杀有关. 这项研究发现抗抑郁药,二和阿片类药物在与中毒有关的自杀中更为常见,突出了需要谨慎的处方和有针对性的预防策略的需要.
科学领域:
- 法医毒理学 法医毒理学
- 公共卫生 公共卫生
- 精神病学是一个精神病学.
背景情况:
- 确定药物使用与自杀之间的关联是复杂的,但对于制定有针对性的自杀预防策略至关重要.
- 了解自杀中涉及的特定物质可以为临床实践和公共卫生干预提供信息.
研究的目的:
- 为了检查各种物质在澳大利亚中毒相关与非中毒相关的自杀事件中的流行率.
- 确定关键药物类别及其与不同自杀机制的关联.
主要方法:
- 一项横截面研究分析了澳大利亚13,664名自杀死者的毒理数据 (2013年7月至2019年10月).
- 自杀被归类为与中毒有关的,如果任何中毒有助于死亡原因.
- 患病率 (PRs) 比较了中毒和非中毒相关自杀之间的物质检测率.
主要成果:
- 与中毒有关的自杀中,抗抑郁药 (PR,1.63),类药 (PR,2.01),非阿片类止痛药 (PR,1.88) 和阿片类药 (PR,2.72) 的使用率更高.
- 在两组中,酒精的普遍性相似 (PR,1.07),而安非他命 (PR,0.68) 和大麻素 (PR,0.67) 在与中毒有关的自杀中较少.
- 在与中毒有关的自杀中,经常观察到多种镇静剂的组合.
结论:
- 与中毒和非中毒相关的自杀都显示了精神药物的高流行率,表明与心理健康问题和物质滥用有关.
- 研究结果表明,应谨慎处方抗抑郁药 (过量服用有毒),镇静剂和阿片类药物等物质.
- 该研究强调了在自杀预防和干预工作中考虑药物毒理学的重要性.
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