在患有随后自身免疫性疾病的儿童中,与罗塔病毒相关的住院治疗
Eun Kyo Ha1, Ju Hee Kim2, Hye Ryeong Cha3
1Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea.
JAMA network open
|July 26, 2023
概括
儿童的罗塔病毒住院治疗显著增加了晚年患自身免疫性疾病的风险. 这一发现突显了病毒感染和自身免疫性疾病发展之间的关键联系.
科学领域:
- 儿童传染病 儿童传染病
- 自体免疫学 自体免疫学
- 流行病学 流行病学
背景情况:
- 罗塔病毒感染是一种常见的儿童疾病,导致胃肠炎.
- 众所周知,它可能会触发自身免疫过程,但确切的关系尚不清楚.
研究的目的:
- 调查轮状病毒感染与儿童自身免疫性疾病的后续风险之间的关联.
主要方法:
- 在韩国 (2002-2017) 进行的一项与人口匹配的队列研究中,包括因轮状病毒住院的86,517名儿童和匹配的对照.
- 考克斯模型被用来估计自身免疫性疾病的危险比率 (HRs),控制混因素.
主要成果:
- 罗塔病毒相关的住院治疗与随后自身免疫性疾病的风险增加24%有关 (HR,1.24;95% CI,1.19-1.28).
- 观察到多种自身免疫综合征的风险增加,并显示与轮状病毒住院人数的剂量依赖关系.
结论:
- 与罗塔病毒相关的住院治疗与儿童自身免疫性疾病的风险增加有显著关联.
- 医疗保健提供者应考虑在有罗塔病毒住院病史的儿童中这种关联.
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