全基因组复制和基因进化在超多样性的有毒胃类动物中
Sarah Farhat1, Maria Vittoria Modica2, Nicolas Puillandre1
1Institut Systématique Evolution Biodiversité (ISYEB), Muséum national d'Histoire naturelle, CNRS, Sorbonne Université, EPHE, Université des Antilles, Paris, France.
Molecular biology and evolution
|July 26, 2023
概括
两种新胃类动物的高质量基因组揭示了整个基因组重复事件. 这项研究为了解海洋牛中毒化合物的演变和物种多样性的了解提供了宝贵的基因组资源.
科学领域:
- 海洋生物学 海洋生物学
- 基因组学就是基因组学.
- 进化生物学是进化的生物学.
背景情况:
- 新胃类动物是多样化的海洋捕食者,具有复杂的毒液系统.
- 之前对新胃类动物的基因组数据有限,质量不均.
- 毒素化合物多样性,基因组进化和新胃类动物过度多样化之间的联系还未得到充分研究.
研究的目的:
- 为了生成高质量的,染色体水平的基因组组合两个新类动物物种.
- 研究基因组进化,包括全基因组复制事件.
- 探索毒液多样性的基因组基础及其与物种多样化的相关性.
主要方法:
- 染色体层次的基因组组合,用于Monoplex corrugatus和斯特拉莫尼塔血.
- 合成块的分析,霍克斯基因集群重复和同义替代.
- 毒毒毒素和ohnolog基因表达的注释和比较分析.
主要成果:
- 生成了高质量的基因组组件 (3Gb和2.2Gb) 每组35个伪染色体.
- 在两种物种中推断出全基因组重复事件.
- 鉴定出毒毒素,但在同类染色体中发现的很少;大多数ohnologs显示了类似的表达特征.
结论:
- 高质量的基因组为新胃类动物研究提供了必不可少的资源.
- 整个基因组复制可能在新胃类动物的进化中发挥作用.
- 需要进一步的研究才能充分理解毒药进化和物种多样化的基因组基础.
相关概念视频
Gene Duplication and Divergence
6.2K
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
6.2K
Genome Size and the Evolution of New Genes
8.0K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
8.0K
Gene Families
8.9K
Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
8.9K
Gene Evolution - Fast or Slow?
7.2K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
7.2K
Exon Recombination
3.6K
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes.
Exon shuffling follows “splice frame rules.” Each exon...
Exon shuffling follows “splice frame rules.” Each exon...
3.6K
Convergent Evolution
27.9K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
27.9K


