在移植接受者中出现de novo尿道狭窄性疾病
Julie Wong1, Sarah Keyes2, David Harriman1
1Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.
概括
新尿道狭窄性疾病影响2.8%的男性移植接受者 (RTRs),通常在移植后呈现症状. 即使没有先前的风险因素,对狭窄的早期考虑至关重要,以管理患者的发病率.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 腎臟病學 (nephrology) 是一種醫學.
- 移植手术 移植手术
背景情况:
- 移植接受者 (RTRs) 可能面临尿道狭窄疾病的风险,原因是常规导管和移植前尿量低.
- 尿道狭窄性疾病是移植后的潜在并发症.
研究的目的:
- 在男性脏移植接受者中描述de novo尿道狭窄症的发病率和特征.
- 确定与移植后尿道狭窄相关的潜在风险因素和结果.
主要方法:
- 对2009年10月至2019年期间发生尿道狭窄的男性RTR进行了回顾性图表审查.
- 对患者特征和结果的描述性和比较性分析.
主要成果:
- 在636名男性RTR中,有18名 (2.8%) 患有术后尿道狭窄,发现的中位时间为56天.
- 77.8%的狭窄患者呈现症状,61.1%需要干预,88.9%的患者有整体移植存活期.
- 尿道狭窄与尿路感染,移植功能延迟或急性排斥之间没有发现显著的关联.
结论:
- 移植后的尿道狭窄发生在一个显著的速度,有助于患者的发病率.
- 尿道狭窄应考虑在RTRs与排泄功能障碍,无论之前的危险因素.
- 建议进行进一步的多中心研究,以探索尿道狭窄和移植存活率之间的关系.
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