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Updated: Jul 21, 2025

Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry
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多层次的方法来检测治疗T细胞受体的自身免疫交叉反应性

Kazusa Ishii1, John S Davies1,2, Andrew L Sinkoe1

  • 1Center for Immuno-Oncology, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.

Science advances
|July 26, 2023
PubMed
概括

开发由T细胞受体 (TCR) 设计的T细胞疗法需要强大的交叉反应性查. 一个新的框架有效地识别了潜在有害的交叉反应性,以获得更安全的癌症治疗方法.

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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries08:49

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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