炎症性肠病儿童的疲劳和身体活动模式
Nanja Bevers1, Els Van de Vijver2, Adrienne Hanssen3
1From the Department of Pediatrics, Zuyderland Medical Center, Sittard-Geleen, the Netherlands.
Journal of pediatric gastroenterology and nutrition
|July 26, 2023
概括
患有炎症性肠病 (IBD) 的儿童经历疲劳,体现出中度至剧烈的体力活动减少. 标准生物标志物没有区分疲劳和非疲劳的儿科IBD患者.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 炎症性肠道疾病研究研究
- 在慢性疾病的临床结果.
背景情况:
- 疲劳是诊断为炎症性肠病 (IBD) 的儿科患者的一个普遍症状.
- 目前对于儿科IBD疲劳的诊断方法主要集中在生物标志物上,如炎症和血红蛋白水平.
- 评估身体活动和日常运作的功能参数在这个人群中仍未得到充分研究.
研究的目的:
- 用生物和功能评估来比较疲劳和非疲劳的儿科IBD患者.
- 确定IBD的疲劳和非疲劳儿童之间的生物标志物和身体活动水平的关键差异.
- 探索潜在的新方法来区分疲劳和非疲劳的儿科IBD患者.
主要方法:
- 一项涉及104名患有轻度至中度疾病活动的儿科IBD患者的横截面研究.
- 疲劳是使用儿科生活质量库存多维疲劳量表 (z分数<-2.0) 定义的.
- 评估疾病特异性生活质量 (IMPACT-III),C反应蛋白 (CRP),便calprotectin (FC),血红蛋白z分数 (Hb z分数),6分钟步行距离 (6MWD z分数) 和三轴加速度计 (TA).
主要成果:
- 疲劳儿童 (n=24) 报告了与非疲劳儿童 (n=80) 相比,疾病特异性生活质量明显降低 (IMPACT-III).
- 两组之间没有观察到Hbz得分,CRP,FC或6MWDz得分的显著差异.
- 三轴加速度计 (TA) 显示,疲劳的患者在中度至强度的体力活动中花费的时间显著减少 (18.3分钟/天) 与非疲劳的患者 (37.3分钟/天) 相比.
结论:
- 标准的生物标志物不足以区分疲劳和非疲劳的儿科IBD患者.
- 三轴加速度计 (TA) 在区分疲劳和非疲劳的个体方面表现有前途.
- 身体活动的功能性评估可能为旨在改善儿童IBD患者疲劳生活质量的干预提供有价值的目标.
相关概念视频
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
356
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
356
01:30Inflammatory Bowel Disease II: Crohn's Disease
296
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
296
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
219
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
219
01:17Chronic Bowel Disorders: Introduction
486
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
486
01:29Inflammatory Bowel Disease IV: Pharmacological Management
154
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
154
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
195
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
195