在使用激素治疗的早产卵巢衰竭中心血管风险因素
Gabriela Pravatta Rezende1, Thamyse Dassie1, Daniela Angerame Yela Gomes1
1Universidade Estadual de Campinas, Campinas, SP, Brazil.
概括
对于过早的卵巢衰竭 (POI) 的激素治疗 (HT) 似乎是安全的,与正常卵巢功能的女性相比,保持类似的心血管风险因素,如血压和脂质. 在HT上有POI的女性也表现出更好的HDL胆固醇水平.
科学领域:
- 内分泌学 在内分泌学.
- 心血管健康 心血管健康
- 妇女健康 妇女健康
背景情况:
- 过早的卵巢缺陷 (POI) 会导致早期的低雌激素,增加长期心血管疾病 (CV) 的风险.
- 激素治疗 (HT) 是一个潜在的干预措施,以减轻POI妇女的CV风险.
研究的目的:
- 为了比较使用HT的POI妇女的心血管风险因素与与正常卵巢功能相匹配的年龄和BMI对照对照.
- 评估HT在POI中控制心血管风险方面的有效性.
主要方法:
- 一项横截面研究,涉及102名在HT上有POI的妇女和102名对照.
- 分析包括脂质特征 (总胆固醇,LDL-C,HDL-C,VLDL-C,甘油三),血糖和动脉血压.
主要成果:
- 两组之间没有观察到血压,血糖或大多数脂质参数的显著差异.
- 在HT上有POI的女性表现出显著更高的HDL-C水平 (p=0.03).
- 高血压和脂质失调的患病率在POI和对照组之间是相似的.
结论:
- 患有POI的女性的HT与血压,脂质和血糖特征与对照组相比较.
- 在POI中,HT似乎不会增加高血压或脂质失调的患病率.
- 使用HT的POI女性表现出有利的HDL-C水平.
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