甲尼达可以引起类似于二硫的反应吗? 一个案例对照研究的倾向与年龄,性别和乙醇度相匹配
Ryan Feldman1,2,3, Rachael Jaszczenski2
1Froedtert & the Medical College of Wisconsin, Department of Pharmacy, Milwaukee, Wisconsin, ryan.feldman@froedtert.com.
概括
在这项研究中,没有证据表明在给近期使用乙醇的患者服用美特罗尼达时会出现类似于迪苏尔菲拉姆的反应. 这些发现表明,归因于这种相互作用的症状更可能是由于酒精本身.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 临床医学 临床医学
背景情况:
- 有争议存在于甲尼达诱导的与乙醇的二硫类反应.
- 病例报告表明严重反应,但受控数据反驳了这一点,没有显示乙甲增加.
- 这项研究旨在评估在使用美特罗尼达和乙醇的患者中发生的二硫类反应的发生率.
研究的目的:
- 追溯评估在已证实使用乙醇并接受了metronidazole的患者中出现dissulfiram类反应的发生率.
- 为了将这些反应的发生率与年龄,性别和乙醇度相匹配的对照组进行比较.
主要方法:
- 对已确认使用乙醇的急诊室患者的回顾性图表审查,这些患者接受了metronidazole.
- 与年龄,性别和乙醇度相匹配的对照组进行比较.
- 在不同组之间比较了已记录的迪苏尔菲拉姆类反应症状发生率.
主要成果:
- 18名患者接受了甲二醇与乙醇;18名匹配对照仅接受了乙醇.
- 两组之间没有观察到与迪苏尔菲拉姆类似作用的显著差异.
- 高血压在美特罗尼达组的发生率明显较低 (16.7%与61.1%相比).
结论:
- 数据支持,在急性护理中,在最近使用的甲化和乙醇之间缺乏类似于二硫的反应.
- 临床影响可能归因于乙醇摄入或潜在疾病,而不是药物相互作用.
- 由于对乙醇相互作用的担忧,不应避免使用美特罗尼达.
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