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Updated: Jul 21, 2025

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
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在微卫星稳定的结直肠癌中,高瘤突变负担 (TMB):多种分子关联表明可变的病理生理学

Ioannis A Voutsadakis1

  • 1Algoma District Cancer Program, Sault Area Hospital, 750 Great Northern Road, Sault Ste Marie, Ontario, P6B 0A8, Canada; Division of Clinical Sciences, Northern Ontario School of Medicine, Sudbury, Ontario, Canada.

Cancer treatment and research communications
|July 26, 2023
PubMed
概括

少数具有熟练不匹配修复 (MMR) 的结直肠癌是微卫星稳定的 (MSS),但具有高瘤突变负担 (TMB). 这些MSS瘤可能在KRAS途径,DNA损伤反应基因和表观遗传调节器中存在突变.

关键词:
生物标志物 生物标志物免疫治疗是一种免疫疗法.微卫星微卫星是什么意思纠正不匹配的修复方法瘤突变负担是瘤突变负担.

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