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Updated: Jul 11, 2026

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模拟导致质瘤的表观遗传病变

Gilbert J Rahme1, Nauman M Javed1, Kaitlyn L Puorro2

  • 1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Departments of Cell Biology and Pathology, Harvard Medical School, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Cell
|July 26, 2023
PubMed
概括

在小鼠细胞中破坏PDGFRA附近的CTCF绝缘体会增加细胞的增殖. 结合Cdkn2a瘤抑制剂的损失,这推动了质瘤的形成,为癌症驱动因素提供了洞察力.

关键词:
在CDKN2ADNA 甲基化IDH 突变美国原产地细胞染色体基因组拓质瘤核架构骨干细胞的前代细胞

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