固体器官移植接种者的第三剂COVID-19疫苗接种后的免疫反应和血清转换:一个元分析
Richard Christian Suteja1, Albert Salim1, I Putu Divanaya Suryanov1
1Faculty of Medicine, Universitas Udayana, Bali, Indonesia.
Transplant immunology
|July 26, 2023
概括
在实体器官移植接受者中进行第三剂COVID-19疫苗接种显示出显著的血清阳性和血清转化率. 这表明这种脆弱人群对COVID-19的免疫力增强.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 移植科学 移植科学
背景情况:
- 根据人口统计数据,COVID-19疫苗的免疫性和有效性各不相同.
- 接受免疫抑制治疗的固体器官移植接受者代表了一个潜在改变疫苗反应的脆弱群体.
研究的目的:
- 评估固体器官移植接受者的血清阳性和血清转化率.
- 评估第三剂COVID-19疫苗接种对该人口免疫反应的影响.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 包括PubMed,Scopus,Cochrane,DOAJ和Clinicaltrials.gov.gov在内的电子数据库的全面搜索
- 对18项报告免疫反应和第三剂疫苗接种后血清转换的全文研究的分析.
主要成果:
- 在第三剂疫苗接种后,集体血清阳性率为67.00%.
- 汇集的血清转化率为52.51%.
- 在基于mRNA (52.38%) 和基于病毒载体 (42.48%) 的助推剂之间,血清转化率有所不同.
结论:
- 第三剂COVID-19疫苗接种在改善固体器官移植接受者的免疫力方面是有效的.
- 这些发现支持使用第三剂疫苗接种来增强移植患者的免疫保护.
- 免疫反应因疫苗类型而异,这凸显了增强剂选择的重要性.
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