抗菌素激素水平升高与体外受精或排卵诱导后的早产无关
Anne E Kim1, Michael K Simoni2, Ashni Nadgauda3
1Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Fertility and sterility
|July 26, 2023
概括
在接受生育治疗的妇女中,抗穆勒激素 (AMH) 水平与早产风险无关. 需要进一步的研究来确定AMH是否可以预测这些患者群体的早产.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 不孕症研究 不孕症研究
背景情况:
- 抗卵巢激素 (AMH) 是卵巢储备的一个关键指标.
- 在接受辅助生殖技术 (ART) 的妇女中,AMH水平与早产风险之间的关系尚未完全理解.
- 多囊卵巢综合征 (PCOS) 与AMH水平升高有关,可能影响怀孕结果.
研究的目的:
- 检查妊娠前AMH水平与早产风险之间的关联.
- 在接受体外受精 (IVF) 或通过子宫内授精 (IUI) 诱导排卵的女性队列中调查这一关联.
- 具体分析女性患有PCOS的相关性.
主要方法:
- 追溯队列研究,包括来自ART周期 (2016-2020) 的活生生的单独出生.
- 排除标准包括缺少AMH,捐赠卵细胞,妊娠载体,多胎妊娠,20周前分娩或 cerclage.
- 分析了AMH水平与早产,怀孕引起的高血压,妊娠糖尿病和妊娠年龄相比较小的相关性.
主要成果:
- 在整体队列中 (n=875),8.4%的分娩是早产,而在预产和早产之间,AMH水平的平均值没有显著差异.
- 超过第75个百分点的AMH水平在满期和早产组中分布相似.
- 没有发现AMH四分位数与早产风险之间的关联,即使经过调整以先前的早产史. 在PCOS亚组 (n=139) 中观察到类似的发现.
结论:
- 增加的AMH水平与通过试管婴儿或排卵诱导怀孕的女性早产风险的增加无关.
- 目前的研究结果表明,AMH可能不是这个人群中早产的可靠预测因素.
- 需要进一步的研究来澄清AMH在接受生育治疗的妇女早产风险分层中的作用.
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