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盘面性翻转现象的无处不在性

Zijian Wang¹, Chenguang Wang¹, Deepak Bahl²

¹Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.

International journal of pharmaceutics

|July 26, 2023

概括

可食性翻转,即一种可食性差的材料与微晶纤维素 (MCC) 得到改善,是一种广泛的现象. 这项研究证实了它在各种材料对中存在,影响了平板电脑制造决策.

科学领域:

材料科学材料科学材料科学
制药科学制药科学
化学工程是化学工程的重要组成部分.

背景情况:

材料的可塑性对于药片开发中的粉末可塑性至关重要.
较高的可塑性通常与由于增加的粘合面积而导致更好的平板性相关.
观察到一种称为"可平板性翻转"的现象,即与微晶纤维素 (MCC) 混合物显示出改善的可平板性,尽管基材的性能差.

研究的目的:

在各种材料系统中调查表表化翻转现象的普遍性.
评估固体形式的药片可用性不佳是否会导致药物产品开发过程中的错误消除.
为了了解压缩压力和可塑性差异在可表化性中的作用.翻转.

主要方法:

测试了六种不同的材料系统,以测试表格性.
包括两个多态对,一个盐/自由酸对,一个晶体/形态固体分散对,以及化学上不同的晶体.
评估了与MCC和一个系统在一个现实的通用药片配方中的二元混合物.

主要成果:

在所有六个测试系统中都观察到平板性翻转.
这种现象发生在与MCC的五种二元混合物和一种现实的配方中.
压缩压力和材料之间的可塑性差异都显著影响了可平板性.

结论:

таблетка性翻转现象在各种不同的制药材料系统中广泛适用.
这一发现表明,最初表化能力较差的材料不应过早丢弃.
对压缩压力和可塑性的进一步研究是有必要的,以优化药片配方.

关键词:

结合区域的结合区域是一般性一般性一般性一般性混合物混合物混合物塑性是一种可塑性.在平板可用性翻转.

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