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在寒冷暴露下SIRT2在肠道屏障中的作用

Jingru Guo¹, Jing Xu¹, Leichong Chen¹

¹Key Laboratory of Bovine Disease Control in Northeast China, Ministry of Agriculture and Rural affairs, Heilongjiang Provincial Key Laboratory of Prevention and Control of Bovine Diseases, College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China.

|July 26, 2023

概括

暴露在寒冷中会损害大肠膜屏障. 通过增强自,从而恢复像ZO-1这样的紧结蛋白,SIRT2淘汰减轻了这种损伤,为肠道屏障障碍提供了潜在的治疗方法.

科学领域:

胃肠病学胃肠病学
细胞生物学细胞生物学
免疫学免疫学免疫学

背景情况:

长时间暴露于寒冷会引起生理压力,并可能危害健康.
肠道环境易受外部压力因素的影响,可能导致损伤和腹等疾病.

研究的目的:

为了研究慢性感冒暴露对骨损伤的影响.
为了阐明Sirtuin 2 (SIRT2) 在寒冷诱导的骨损伤中的作用.

主要方法:

在C57BL6和SIRT2淘汰小鼠中建立了一种慢性感冒暴露模型.
评估了肠道的透性,形态,超结构和蛋白质表达 (西式涂抹,光染色).
在MODE-K细胞的体外研究中,探索了与紧密结合相关的内等质网膜应激,SIRT2和自.

主要成果:

长期暴露于寒冷会导致阴道上皮质屏障损伤和内分泌网膜压力.
通过促进自,SIRT2敲击减轻了因感冒引起的阴茎损伤.
在压力下,增强的自恢复了紧结蛋白ZO-1的表达.

结论:

SIRT2在调解寒冷诱导的阴茎损伤方面发挥着至关重要的作用.
自活性激活是缓解因暴露于寒冷而引起的肠壁损伤的关键机制.
这些发现为炎症性肠病 (IBD) 和其他肠道屏障疾病提供了潜在的治疗点.

关键词:

自自是一种自的过程.压力ERER压力ERER压力在FoxO1上,FoxO1是FoxO1的第一个代号.肠道屏障肠道屏障肠道屏障在SIRT2中,SIRT2是SIRT2.紧密的结口紧密的结口.

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