遗传多态度对怀孕期间甲基化效率的影响:来自西班牙出生队列的证据
Raquel Soler-Blasco1, Florencia Harari2, Gabriel Riutort-Mayol3
1Department of Nursing, Universitat de València, Valencia, Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
The Science of the total environment
|July 26, 2023
概括
在怀孕期间,AS3MT和FOLH1的遗传变异会影响无机甲基化. 这项研究确定了影响怀孕个体代谢的遗传因素,这对于了解人口易感性至关重要.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 人类遗传学 人类遗传学
背景情况:
- 无机 (iAs) 是一种有毒的金属化物,已知代谢和毒性受到遗传多态化的影响.
- 在怀孕期间对IA代谢的研究是有限的,需要对母亲遗传因素进行研究.
研究的目的:
- 研究关键基因 (AS3MT,GSTO2,N6AMT1,MTHFR,MTR,FTCD,CBS,FOLH1) 中的遗传多态化对孕妇无机甲基化效率的影响.
- 为了确定与怀孕早期代谢变异相关的特定基因变异.
主要方法:
- 分析了INMA西班牙队列中541名孕妇参与者的尿样,以测量代谢物 (iAs,MMA,DMA).
- 使用代谢物相对度来确定IA甲基化效率.
- 在9个基因中的32个单核酸多态 (SNPs) 的基因定型和AS3MT的单核型推断.
- 应用多变量线性回归模型来评估基因型/亚型与甲基化效率之间的关联.
主要成果:
- AS3MT SNPs (rs3740393,rs3740390,rs11191453,rs11191454) 的祖先等位基因与较高的%MMA,%iAs和较低的%DMA有关.
- 一种特定的AS3MT单元型 (GGCTTCAC) 与%MMA的增加有关.
- FOLH1 SNP rs202676显示出与甲基化效率的统计学上显著的关联.
结论:
- 遗传变异,特别是AS3MT的祖先等位基因,与怀孕早期有机甲基化效率降低有关.
- FOLH1基因似乎也在调节甲基化中的作用.
- 代谢是多基因的,根据遗传特征识别易感人群对于公共卫生干预至关重要.
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