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Updated: Jul 21, 2025

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
06:45

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Published on: October 4, 2021

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在表达D1受体的条状投射神经元中,BDNF/TrkB通路的激活对L-DOPA诱导的运动障碍起着保护作用

Assunta Pelosi1, Yukari Nakamura1, Jean-Antoine Girault1

  • 1Inserm UMR-S 1270, Paris, France; Sorbonne University, Science and Engineering Faculty, Paris, France; Institut du Fer à Moulin, Paris, France.

Neurobiology of disease
|July 26, 2023
PubMed
概括

在帕金森病中,L-DOPA诱导的动力障碍 (LID) 由D1受体神经元中的TrkB缺失恶化. BDNF/TrkB信号似乎对LID有保护作用,这表明TrkB激动剂可能会降低其严重程度.

关键词:
6-OHDA 的损伤不正常的非自愿运动.多巴胺是一种多巴胺.运动障碍症是指运动障碍.埃尔克·埃尔克是什么意思神经营养素的神经营养素帕金森病的疾病.状体是一个状体.

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