在博茨瓦纳树木相关的Cryptococcus neoformans的流行,分子和表型概况
Kgomotso Tshekiso1, Daniel Loeto1, Mbaki Muzila1
1Department of Biological Sciences, Faculty of Science, University of Botswana, Private Bag 0022, Gaborone, Botswana.
Fungal biology
|July 26, 2023
概括
一种真菌病原体Cryptococcus neoformans在博茨瓦纳的树上被发现,其中包括Mopane. 隔离物显示抗真菌耐药性和生物膜形成,构成公共卫生风险.
科学领域:
- 环境微生物学环境微生物学
- 医学真菌学 医学真菌学
- 公共卫生 公共卫生
背景情况:
- 新型菌 (Cryptococcus neoformans) 是一种机会主义的真菌病原体.
- 它会引起密码球菌病,主要发生在免疫受损的个体中.
- 摩潘树是C. neoformans的已知生态利基.
研究的目的:
- 调查C. neoformans在博茨瓦纳本土树木上的流行情况.
- 为了在表型和基因型上表征C. neoformans分离物.
- 评估抗真菌耐药菌株对公共卫生的影响.
主要方法:
- 在C. neoformans中从Colophospermum mopane,Acacia tortilis,Adansonia digitata和Ziziphus mucronata中分离和识别C. neoformans. 在C.
- 现型特征包括抗真菌耐药性 (富可纳) 和生物膜形成.
- 基因型特征,包括交配类型和遗传结构分析.
主要成果:
- 在C. mopane中,C. neoformans的发病率为7.1%,在其他树木中为2.9%.
- 所有的分离物是非野生类型 (非WT) 的流可纳.
- 65%的分离物是生物膜生产者.
- 很高的比例 (53%) 是罕见的MATa交配类型,其中有一种混合.
- 基因型包括VNI (71%),VNB (23%) 和混合体.
结论:
- 博茨瓦纳的本土树木作为抗真菌耐药C. neoformans的替代生态.
- 耐药菌株和杂交的存在表明性重组的潜力.
- 根据"一个健康"的方法加强监测和风险评估对于保护公共健康至关重要.
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